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Issue 100, 2019
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A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

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Abstract

A lipase-triggered drug release nanoplatform (PGL-DPP–FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP–FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP–FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.

Graphical abstract: A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

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Publication details

The article was received on 30 Oct 2019, accepted on 25 Nov 2019 and first published on 25 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08463K
Chem. Commun., 2019,55, 15145-15148

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    A lipase-responsive antifungal nanoplatform for synergistic photodynamic/photothermal/pharmaco-therapy of azole-resistant Candida albicans infections

    D. Yang, X. Lv, L. Xue, N. Yang, Y. Hu, L. Weng, N. Fu, L. Wang and X. Dong, Chem. Commun., 2019, 55, 15145
    DOI: 10.1039/C9CC08463K

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