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NHC-catalyzed Silylative Dehydration of Primary Amides to Nitriles at Room Temperature

Abstract

Herein we report an abnormal N-heterocyclic carbene catalyzed dehydration of primary amides in presence of a silane. This process bypasses the energy-demanding 1,2-siloxane elimination step usually required for metal/silane catalyzed reactions. A detailed mechanistic cycle of this process has been proposed based on experimental evidences along with computational study.

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Publication details

The article was received on 28 Oct 2019, accepted on 29 Nov 2019 and first published on 29 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08413D
Chem. Commun., 2019, Accepted Manuscript

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    NHC-catalyzed Silylative Dehydration of Primary Amides to Nitriles at Room Temperature

    S. K. Mandal, P. K. Hota, S. Maji, J. Ahmed and N. M. Rajendran, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC08413D

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