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Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

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Abstract

A kind of light-responsive vesicle was prepared by aqueous self-assembly of α-CD and an azobenzene-containing M-helical foldamer, which displayed dynamic disassembly–reassembly structural transformation when alternately irradiated by UV and visible light. Distinctively, this vesicle also exhibited enantioselective release abilities toward racemic propranolol (a β-blocker), owing to the M-helical building blocks.

Graphical abstract: Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

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Publication details

The article was received on 26 Oct 2019, accepted on 25 Nov 2019 and first published on 28 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08380D
Chem. Commun., 2020, Advance Article

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    Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

    T. Yan, F. Li, S. Qi, J. Tian, R. Tian, J. Hou, Q. Luo, Z. Dong, J. Xu and J. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08380D

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