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Pyridinium 1,4-Zwitterionic Thiolates as a useful Class of Sulfur-containing Synthons: Application to the Synthesis of 2,5-Dihydro-1,4,5-thiadiazepines

Abstract

A novel [4+3] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates with azoalkenes derived from α-halo hydrazones in situ has been developed, which allows expedient access to an array of 2,5-dihydro-1,4,5-thiadiazepines. Libraries of highly functionalized sulfoxide and sulfone analogues of 2,5-dihydro-1,4,5-thiadiazepines were also obtained via selective oxidation with m-CPBA.

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Publication details

The article was received on 24 Oct 2019, accepted on 05 Nov 2019 and first published on 05 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08326J
Chem. Commun., 2019, Accepted Manuscript

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    Pyridinium 1,4-Zwitterionic Thiolates as a useful Class of Sulfur-containing Synthons: Application to the Synthesis of 2,5-Dihydro-1,4,5-thiadiazepines

    B. Cheng, Y. Li, T. Wang, X. Zhang, H. Li, Y. Li and H. Zhai, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC08326J

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