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A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

Abstract

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.

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Publication details

The article was received on 19 Oct 2019, accepted on 04 Nov 2019 and first published on 05 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08199B
Chem. Commun., 2019, Accepted Manuscript

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    A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

    J. Gao, H. Yu, F. Chen, X. Hu, Y. Wang and D. Guo, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC08199B

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