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Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities

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Abstract

A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. The topologically nanoengineered polypeptides show superior antimicrobial activity against Gram-positive and Gram-negative bacteria and low toxicity, allowing screening of architectural polypeptides as mimics of host defense peptides for antimicrobials.

Graphical abstract: Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities

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Publication details

The article was received on 15 Oct 2019, accepted on 03 Dec 2019 and first published on 04 Dec 2019


Article type: Communication
DOI: 10.1039/C9CC08095C
Chem. Commun., 2020, Advance Article

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    Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities

    Y. Zhang, W. Song, S. Li, D. Kim, J. H. Kim, J. R. Kim and I. Kim, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08095C

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