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A novel method to engineer proteases for selective enzyme inhibition

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Abstract

In this work, we have proposed a new strategy to expand the function of a protein. By taking a protease as an example, it can be engineered to make up the shortcoming of natural proteases, and thus it can efficiently and selectively hydrolyze a desired protein even in a complex biological fluid.

Graphical abstract: A novel method to engineer proteases for selective enzyme inhibition

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Publication details

The article was received on 15 Oct 2019, accepted on 29 Oct 2019 and first published on 30 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC08085F
Chem. Commun., 2019, Advance Article

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    A novel method to engineer proteases for selective enzyme inhibition

    L. Li, H. Shi, A. Sheng, Y. Yang, L. Shi, C. Li and G. Li, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC08085F

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