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Issue 98, 2019
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A cyotosol-selective nitric oxide bomb as a new paradigm of an anticancer drug

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Abstract

We have reported rational design of a polymeric NO delivery micelle as a cytosol-selective NO bomb. Protected NO-donors are released from the micelle under endolysosomal conditions, and then deprotected by cytosolic glutathione. Cytosol-selective NO delivery facilitates significant tumor regression without the aid of other therapeutic modalities even in intravenous administrations.

Graphical abstract: A cyotosol-selective nitric oxide bomb as a new paradigm of an anticancer drug

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Publication details

The article was received on 13 Oct 2019, accepted on 14 Nov 2019 and first published on 14 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08028G
Chem. Commun., 2019,55, 14789-14792

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    A cyotosol-selective nitric oxide bomb as a new paradigm of an anticancer drug

    D. Park, S. Im, G. Saravanakumar, Y. M. Lee, J. Kim, K. Kim, J. Lee, J. Kim and W. J. Kim, Chem. Commun., 2019, 55, 14789
    DOI: 10.1039/C9CC08028G

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