A cyotosol-selective nitric oxide bomb as a new paradigm of an anticancer drug†
We have reported rational design of a polymeric NO delivery micelle as a cytosol-selective NO bomb. Protected NO-donors are released from the micelle under endolysosomal conditions, and then deprotected by cytosolic glutathione. Cytosol-selective NO delivery facilitates significant tumor regression without the aid of other therapeutic modalities even in intravenous administrations.
- This article is part of the themed collection: Celebrating the 75th Anniversary of the Korean Chemical Society (KCS)