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Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

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Abstract

Direct enantioselective Mannich reactions of α-azido cyclic ketones with aldimines are realized through chiral phosphoric acid catalysis, which generate chiral azides possessing an α-quanternary stereocenter with complete regioselectivities and high diastereoselectivities and enantioselectivities.

Graphical abstract: Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

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Publication details

The article was received on 12 Oct 2019, accepted on 25 Nov 2019 and first published on 25 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08000G
Chem. Commun., 2020, Advance Article

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    Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

    X. Ye, Y. Pan and X. Yang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08000G

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