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Optically-Controlled Supramolecular Self-assembly of Antibiotic for Antibacterial Regulation

Abstract

To address the severe issue of bacterial resistance, self-assembly supramolecular system of antitibiotics were rapidly developed due to its regulation of antibacterial activity. However, the intervention of exogenous guest molecule in supramolecular system limit their potential application. In this paper, we designed and synthesized a new photo-responsive norfloxacin antibiotic (azobenzene-norfloxacin). This antibiotic exhibits low antibacterial activity for trans state of azobenzene unit while high activity for cis state. Then, α cyclodextrin (αCD) was introduced into the trans-azobenzene-norfloxacin through host-guest interactions, and this supramolecular exhibited higher “on-off” ratio of antibacterial ability in comparison to azobenzene-norfloxacin alone. When needed at any time, disassembled process between the αCD and azobenzene-norfloxacin could be triggered by the UV light due to the conformation change of azobenzene unit from trans into cis state to turn on the antibacterial activity. This work offers an approach to efficiently regulate the activity of antibiotics by combing the supramolecular and light-regulating strategies together, which has a great potential to relieve the emergence of bacterial resistance.

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Publication details

The article was received on 12 Oct 2019, accepted on 07 Nov 2019 and first published on 08 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07999H
Chem. Commun., 2019, Accepted Manuscript

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    Optically-Controlled Supramolecular Self-assembly of Antibiotic for Antibacterial Regulation

    X. Fu, H. Bai, R. Qi, H. Zhao, K. Peng, F. Lv, L. Liu and S. Wang, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC07999H

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