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We report a supramolecular photo-responsive antibiotic (azobenzene-norfloxacin/αCD). This supramolecule exhibited a higher “on–off” ratio of antibacterial ability than azobenzene-norfloxacin alone under UV irradiation. It offers an approach to efficiently regulate the activity of antibiotics by combining the supramolecular and light-regulating strategies together.

Graphical abstract: Optically-controlled supramolecular self-assembly of an antibiotic for antibacterial regulation

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