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An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

Abstract

A combinatorial approach using a One-Bead-One-Compound method and a screening based on an SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effect when cells were submitted to oxidative stress.

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Publication details

The article was received on 09 Oct 2019, accepted on 20 Nov 2019 and first published on 20 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07920C
Chem. Commun., 2019, Accepted Manuscript

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    An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

    A. Vincent, J. R. Fores, E. Tauziet, E. Quévrain, Á. Dancs, A. Conte-Daban, A. Bernard, P. Pelupessy, K. Coulibaly, P. Seksik, C. Hureau, K. Selmeczi, C. Policar and N. Delsuc, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC07920C

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