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Issue 3, 2020
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An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

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Abstract

A combinatorial approach using a one-bead-one-compound method and a screening based on a SOD-activity assay was set up for the discovery of an efficient peptidyl copper complex. The complex exhibited good stability constants, suitable redox potentials and excellent intrinsic activity. This complex was further assayed in cells for its antioxidant properties and showed beneficial effects when cells were subjected to oxidative stress.

Graphical abstract: An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

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Article information


Submitted
09 Oct 2019
Accepted
20 Nov 2019
First published
20 Nov 2019

Chem. Commun., 2020,56, 399-402
Article type
Communication

An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

A. Vincent, J. R. Fores, E. Tauziet, E. Quévrain, Á. Dancs, A. Conte-Daban, A. Bernard, P. Pelupessy, K. Coulibaly, P. Seksik, C. Hureau, K. Selmeczi, C. Policar and N. Delsuc, Chem. Commun., 2020, 56, 399
DOI: 10.1039/C9CC07920C

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