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Issue 99, 2019
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Late-stage difluoromethylation leading to a self-immobilizing fluorogenic probe for the visualization of enzyme activities in live cells

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Abstract

Reported herein is a novel p-quinone methide-based self-immobilizing fluorogenic probe for the visualization of β-galactosidase activities in live cells. This easily prepared imaging reagent massively increases the fluorescence intensity and covalently links to the activation site with high efficiency upon enzymatic trigger.

Graphical abstract: Late-stage difluoromethylation leading to a self-immobilizing fluorogenic probe for the visualization of enzyme activities in live cells

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Publication details

The article was received on 09 Oct 2019, accepted on 19 Nov 2019 and first published on 19 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07903C
Chem. Commun., 2019,55, 15000-15003

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    Late-stage difluoromethylation leading to a self-immobilizing fluorogenic probe for the visualization of enzyme activities in live cells

    J. Jiang, Q. Tan, S. Zhao, H. Song, L. Hu and H. Xie, Chem. Commun., 2019, 55, 15000
    DOI: 10.1039/C9CC07903C

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