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Issue 99, 2019
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Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

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Abstract

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic targeting spermine unit, and a hydrophobic stearyl chain. The amphiphilic drug conjugates were further assembled into the corresponding micelles and evaluated in vitro for the active targeting of tumor cells overexpressing the polyamine transport system.

Graphical abstract: Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

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Publication details

The article was received on 08 Oct 2019, accepted on 20 Nov 2019 and first published on 20 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07883E
Chem. Commun., 2019,55, 14968-14971

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    Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

    J. Alliot, I. Theodorou, F. Ducongé, E. Gravel and E. Doris, Chem. Commun., 2019, 55, 14968
    DOI: 10.1039/C9CC07883E

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