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Issue 99, 2019
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Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

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Abstract

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic targeting spermine unit, and a hydrophobic stearyl chain. The amphiphilic drug conjugates were further assembled into the corresponding micelles and evaluated in vitro for the active targeting of tumor cells overexpressing the polyamine transport system.

Graphical abstract: Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

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Article information


Submitted
08 Oct 2019
Accepted
20 Nov 2019
First published
20 Nov 2019

Chem. Commun., 2019,55, 14968-14971
Article type
Communication

Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

J. Alliot, I. Theodorou, F. Ducongé, E. Gravel and E. Doris, Chem. Commun., 2019, 55, 14968
DOI: 10.1039/C9CC07883E

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