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Digital quantitative detection of serum circulating miRNAs using dual-enhanced magnetobiosensors based on cascaded nucleic acid circuits

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Abstract

The tough challenges for the convenient and quantitative determination of circulating miRNAs (cmiRNAs) in the peripheral blood are low abundance, high interference and lack of direct digital readout. Here, we developed dual-enhanced magnetobiosensors based on cascaded nucleic acid circuits, which integrate catalyzed hairpin assembly (CHA) with the hybridization chain reaction (HCR), for sensitive, portable and digital quantitative detection of circulating miRNAs in serum by a personal glucose meter (PGM).

Graphical abstract: Digital quantitative detection of serum circulating miRNAs using dual-enhanced magnetobiosensors based on cascaded nucleic acid circuits

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Publication details

The article was received on 06 Oct 2019, accepted on 22 Oct 2019 and first published on 22 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07841J
Chem. Commun., 2019, Advance Article

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    Digital quantitative detection of serum circulating miRNAs using dual-enhanced magnetobiosensors based on cascaded nucleic acid circuits

    C. Liu, Y. An, Y. Zhang, X. Li, Q. Xue and H. Wang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07841J

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