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Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy

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Abstract

Herein, we have designed bifunctional composite nanospheres for carcinoembryonic antigen (CEA) sensing and targeted drug delivery, based on carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels. As a result, highly sensitive and selective CEA detection was achieved in vitro, and an effective cytotoxic effect was realized in vivo after loading doxorubicin.

Graphical abstract: Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy

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Publication details

The article was received on 07 Oct 2019, accepted on 20 Nov 2019 and first published on 20 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07831B
Chem. Commun., 2019, Advance Article

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    Green-emitting carbon dot loaded silica nanoparticles coated with DNA-cross-linked hydrogels for sensitive carcinoembryonic antigen detection and effective targeted cancer therapy

    X. Ji, H. Lv, X. Sun and C. Ding, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07831B

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