Issue 100, 2019
From the journal:

Chemical Communications

Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles†

Arnaud Peramo,a   Anaëlle Dumas,a   Hynd Remita, ORCID logo b   Mireille Benoît,b   Stephanie Yen-Nicolay,c   Raphaël Corre,d   Ruy A. Louzada,d   Corinne Dupuy,d   Shannon Pecnard,a   Benoit Lambert,e   Jacques Young,e   Didier Desmaële ORCID logo a  and  Patrick Couvreur ORCID logo *a  

* Corresponding authors

a Institut Galien Paris-Sud, UMR 8612, CNRS Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie 5 rue Jean-Baptiste Clément, 92290 Chatenay-Malabry, France
E-mail: patrick.couvreur@u-psud.fr

b Laboratoire de Chimie Physique, UMR 8000-CNRS, Bâtiment 349, Université Paris-Sud, Université Paris-Saclay, Rue Michel Magat, 91400 Orsay, 91405 Orsay, France

c Trans-Prot, UMS IPSIT, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie 5 rue JB Clément, 92296 Châtenay-Malabry, France

d Institut de Cancérologie Gustave Roussy, UMR8200 CNRS, 114 rue Edouard Vaillant, 94805 Villejuif, France

e Hôpital Bicêtre, 78 rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France

Abstract

We have developed new benign palladium nanoparticles able to catalyze the Suzuki–Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients’ tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.

Graphical abstract: Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

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Article information

DOI
https://doi.org/10.1039/C9CC07803G
Article type
Communication
Submitted
04 Oct 2019
Accepted
18 Nov 2019
First published
29 Nov 2019

Chem. Commun., 2019,55, 15121-15124

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Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

A. Peramo, A. Dumas, H. Remita, M. Benoît, S. Yen-Nicolay, R. Corre, R. A. Louzada, C. Dupuy, S. Pecnard, B. Lambert, J. Young, D. Desmaële and P. Couvreur, Chem. Commun., 2019, 55, 15121 DOI: 10.1039/C9CC07803G

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