Jump to main content
Jump to site search


Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

Author affiliations

Abstract

We have developed new benign palladium nanoparticles able to catalyze the Suzuki–Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients’ tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.

Graphical abstract: Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Oct 2019, accepted on 18 Nov 2019 and first published on 29 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07803G
Chem. Commun., 2019, Advance Article

  •   Request permissions

    Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles

    A. Peramo, A. Dumas, H. Remita, M. Benoît, S. Yen-Nicolay, R. Corre, R. A. Louzada, C. Dupuy, S. Pecnard, B. Lambert, J. Young, D. Desmaële and P. Couvreur, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07803G

Search articles by author

Spotlight

Advertisements