Visible-light-induced intramolecular sp3 C–H oxidation of 2-alkyl-substituted benzamides for the synthesis of functionalized iminoisobenzofurans

Abstract

We have developed a protocol for the synthesis of functionalized iminoisobenzofurans by means of visible-light-induced intramolecular cyclization reactions of 2-alkyl-substituted benzamides. This one step-economical protocol, which involves intramolecular sp³ C–O bond formation, features mild reaction conditions, exclusive chemoselectivity, and high yields.