Jump to main content
Jump to site search


A fluorescent probe for butyrylcholinesterase activity in human serum based on a fluorophore with specific binding affinity for human serum albumin

Author affiliations

Abstract

Non-specific binding of a fluorescent probe to human serum albumin is problematic because it induces signal interference when the probe detects the target biomarker in human serum. To eliminate this problem, we used intrinsically problematic non-specific fluorescence in designing a fluorescent probe for butyrylcholinesterase activity in serum. The probe containing a fluorophore with specific binding affinity for albumin could sensitively detect butyrylcholinesterase activity in serum with high selectivity to acetylcholinesterase and screen the efficiency of butyrylcholinesterase inhibitors.

Graphical abstract: A fluorescent probe for butyrylcholinesterase activity in human serum based on a fluorophore with specific binding affinity for human serum albumin

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Oct 2019, accepted on 23 Oct 2019 and first published on 23 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07737E
Chem. Commun., 2019, Advance Article

  •   Request permissions

    A fluorescent probe for butyrylcholinesterase activity in human serum based on a fluorophore with specific binding affinity for human serum albumin

    S. Yoo and M. S. Han, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07737E

Search articles by author

Spotlight

Advertisements