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Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

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Abstract

The products of three terpene synthases from two social amoebae, Dictyostelium discoideum and Dictyostelium purpureum, were identified, showing sesquiterpene synthase activity for one and diterpene synthase activity for the other two enzymes. Site-directed mutagenesis experiments revealed the importance of a newly identfied highly conserved residue for catalytic activity. For one of the enzyme products, β-araneosene, a bromonium ion induced transannular cyclisation was investigated, yielding the first brominated derivatives of this diterpene.

Graphical abstract: Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

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Publication details

The article was received on 30 Sep 2019, accepted on 11 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07681F
Chem. Commun., 2019, Advance Article

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    Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

    J. Rinkel, T. G. Köllner, F. Chen and J. S. Dickschat, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07681F

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