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Visible-Light-Promoted Oxidative Halogenation of Alkynes

Abstract

In nature, halogenation promotes the biological activity of secondary metabolites, especially geminal dihalogenation. Related natural molecules have been studied for decades. In recent years, their diversified vital activities have been explored for treating various diseases, which call for efficient and divergent synthetic strategies to facilitate drug discovery. Here we report a catalyst-free oxidative halogenation achieved under ambient conditions (halide ion, air, water, visible light, room temperature, and normal pressure). Constitutionally, electron transfer between oxygen and halide ion is shuttled via simple conjugated molecules, in which phenylacetylene works as both reactant and catalyst. Synthetically, it provides a highly compatible late-stage transformation strategy to build up dihaloacetophenones (DHAPs).

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Publication details

The article was received on 30 Sep 2019, accepted on 22 Oct 2019 and first published on 23 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07655G
Chem. Commun., 2019, Accepted Manuscript

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    Visible-Light-Promoted Oxidative Halogenation of Alkynes

    Y. Li, T. Mou, L. Lu and X. Jiang, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC07655G

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