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A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

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Abstract

Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit into a chemical entity remains a significant challenge from a synthetic point of view. Here, we have presented a new approach for the installation of the BCP unit on the xanthate moiety by means of a radical exchange process.

Graphical abstract: A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

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Publication details

The article was received on 30 Sep 2019, accepted on 20 Nov 2019 and first published on 21 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07610G
Chem. Commun., 2019, Advance Article

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    A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

    S. K. Rout, G. Marghem, J. Lan, T. Leyssens and O. Riant, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07610G

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