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Issue 99, 2019
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A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

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Abstract

Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit into a chemical entity remains a significant challenge from a synthetic point of view. Here, we have presented a new approach for the installation of the BCP unit on the xanthate moiety by means of a radical exchange process.

Graphical abstract: A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

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Article information


Submitted
30 Sep 2019
Accepted
20 Nov 2019
First published
21 Nov 2019

Chem. Commun., 2019,55, 14976-14979
Article type
Communication

A radical exchange process: synthesis of bicyclo[1.1.1]pentane derivatives of xanthates

S. K. Rout, G. Marghem, J. Lan, T. Leyssens and O. Riant, Chem. Commun., 2019, 55, 14976
DOI: 10.1039/C9CC07610G

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