Issue 87, 2019
From the journal:

Chemical Communications

S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells†

Xiaohan Xu, ORCID logo ‡a   Haibo Wang, ORCID logo ‡a   Hongyan Li, ORCID logo a   Xuqiao Hu,a   Yu Zhang,b   Xinyuan Guan, ORCID logo b   Patrick H. Toy ORCID logo a  and  Hongzhe Sun ORCID logo *a  

* Corresponding authors

a Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
E-mail: hsun@hku.hk

b Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, P. R. China

Abstract

Histone H3.3 was identified as an arsenic-binding protein of S-dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents.

Graphical abstract: S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC07605K
Article type
Communication
Submitted
27 Sep 2019
Accepted
09 Oct 2019
First published
11 Oct 2019

Chem. Commun., 2019,55, 13120-13123

Permissions

Request permissions

S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

X. Xu, H. Wang, H. Li, X. Hu, Y. Zhang, X. Guan, P. H. Toy and H. Sun, Chem. Commun., 2019, 55, 13120 DOI: 10.1039/C9CC07605K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements