Jump to main content
Jump to site search


S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

Author affiliations

Abstract

Histone H3.3 was identified as an arsenic-binding protein of S-dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents.

Graphical abstract: S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Sep 2019, accepted on 09 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07605K
Chem. Commun., 2019, Advance Article

  •   Request permissions

    S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells

    X. Xu, H. Wang, H. Li, X. Hu, Y. Zhang, X. Guan, P. H. Toy and H. Sun, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07605K

Search articles by author

Spotlight

Advertisements