Issue 4, 2020

Supramolecular recognition of phosphocholine by an enzyme-like cavitand receptor

Abstract

The first example of supramolecular recognition of phosphocholine by a cavitand receptor has been reported here. The chemical structure of the receptor has been optimized by DFT calculations. The recognition mechanism is based on a “multi-topic approach”, which leads to highly efficient (K value up to 107 M−1), selective and sensitive (ppb level) sensing of phosphocholine. The recognition mechanism proposed here is similar to those exploited by Nature, and paves the way for the realization of new sensors with important applications in medicine and security fields.

Graphical abstract: Supramolecular recognition of phosphocholine by an enzyme-like cavitand receptor

Supplementary files

Article information

Article type
Communication
Submitted
26 Sep 2019
Accepted
18 Oct 2019
First published
21 Oct 2019

Chem. Commun., 2020,56, 539-542

Supramolecular recognition of phosphocholine by an enzyme-like cavitand receptor

L. Legnani, R. Puglisi, A. Pappalardo, M. A. Chiacchio and G. Trusso Sfrazzetto, Chem. Commun., 2020, 56, 539 DOI: 10.1039/C9CC07577A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements