Supramolecular Recognition of Phosphocholine by Enzyme-Like Cavitand Receptor
The first example of supramolecular recognition of phosphocholine by a cavitand receptor has been here reported. The chemical structure of the receptor has been optimized by DFT calculation. The recognition mechanism is based on a “multi-topic approach”, which leads to high efficient (K value up to 107 M-1), selective and sensitive (ppb level) sensing of phosphocholine. The recognition mechanism here proposed is similar to those exploited by the Nature, and paves the way for the realization of new sensors with important applications in medicine and security fields.