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Issue 97, 2019
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Thermoresponsive drug delivery to mitochondria in vivo

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Abstract

Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.

Graphical abstract: Thermoresponsive drug delivery to mitochondria in vivo

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Article information


Submitted
25 Sep 2019
Accepted
11 Nov 2019
First published
11 Nov 2019

Chem. Commun., 2019,55, 14645-14648
Article type
Communication

Thermoresponsive drug delivery to mitochondria in vivo

L. Ruan, M. Zhou, J. Chen, H. Huang, J. Zhang, H. Sun, Z. Chai and Y. Hu, Chem. Commun., 2019, 55, 14645
DOI: 10.1039/C9CC07538K

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