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A nanoscale metal–organic framework for combined photodynamic and starvation therapy in treating breast tumors

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Abstract

We demonstrate herein an effective cascade reaction for combined photodynamic and starvation therapy in treating breast tumors based on a photosensitizer and CO prodrug decorated NMOF. The PDT-induced ROS can further trigger CO release, and the high antitumor efficiency derived from both 1O2 and CO is well confirmed by in vitro assays and in vivo trials.

Graphical abstract: A nanoscale metal–organic framework for combined photodynamic and starvation therapy in treating breast tumors

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Publication details

The article was received on 24 Sep 2019, accepted on 29 Oct 2019 and first published on 29 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07510K
Chem. Commun., 2019, Advance Article

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    A nanoscale metal–organic framework for combined photodynamic and starvation therapy in treating breast tumors

    Q. Guan, L. Zhou, Y. Li and Y. Dong, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07510K

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