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Issue 98, 2019
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Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis

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Abstract

We propose a novel fluorescence assay method by designing a polymerization-driven DNA dominoes collapse (PDDC) strategy, enabling highly sensitive detection of p53 gene (as a model analyte) and single nucleotide polymorphism analysis.

Graphical abstract: Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis

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Supplementary files

Article information


Submitted
24 Sep 2019
Accepted
17 Nov 2019
First published
18 Nov 2019

Chem. Commun., 2019,55, 14797-14800
Article type
Communication

Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis

H. Dong, B. Lu, J. Wang, J. Xie, K. Liu, L. Jia and J. Zhuang, Chem. Commun., 2019, 55, 14797
DOI: 10.1039/C9CC07508A

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