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Pd-Catalyzed regio- and enantioselective allylic substitution with 2-pyridones

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Abstract

An efficient method for the asymmetric synthesis of N-substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd2(dba)3·CHCl3 and phosphoramidite L2 as a ligand, the process allowed rapid access to N-substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.

Graphical abstract: Pd-Catalyzed regio- and enantioselective allylic substitution with 2-pyridones

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Publication details

The article was received on 24 Sep 2019, accepted on 07 Oct 2019 and first published on 08 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07482A
Chem. Commun., 2019, Advance Article

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    Pd-Catalyzed regio- and enantioselective allylic substitution with 2-pyridones

    S. Khan, B. H. Shah, I. Khan, M. Li and Y. J. Zhang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07482A

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