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A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

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Abstract

A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on the membrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice.

Graphical abstract: A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

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Publication details

The article was received on 23 Sep 2019, accepted on 04 Oct 2019 and first published on 05 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07460K
Chem. Commun., 2019, Advance Article

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    A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

    X. Guo, R. C. H. Wong, Y. Zhou, D. K. P. Ng and P. Lo, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07460K

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