Jump to main content
Jump to site search


Aldehyde-mediated bioconjugation via in situ generated ylides

Author affiliations

Abstract

A technically simple approach for rapid, high-yielding and site-selective bioconjugation has been developed for both in vitro and cellular applications. This method involves the generation of maleimido-phosphonium ylides via 4-nitrophenol catalysis under physiological conditions followed by their Wittig reactions with aldehyde-appended biomolecules.

Graphical abstract: Aldehyde-mediated bioconjugation via in situ generated ylides

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Sep 2019, accepted on 19 Nov 2019 and first published on 19 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07443K
Chem. Commun., 2019, Advance Article

  •   Request permissions

    Aldehyde-mediated bioconjugation via in situ generated ylides

    S. Parmar, S. P. Pawar, R. Iyer and D. Kalia, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07443K

Search articles by author

Spotlight

Advertisements