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Issue 99, 2019
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Aldehyde-mediated bioconjugation via in situ generated ylides

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Abstract

A technically simple approach for rapid, high-yielding and site-selective bioconjugation has been developed for both in vitro and cellular applications. This method involves the generation of maleimido-phosphonium ylides via 4-nitrophenol catalysis under physiological conditions followed by their Wittig reactions with aldehyde-appended biomolecules.

Graphical abstract: Aldehyde-mediated bioconjugation via in situ generated ylides

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Article information


Submitted
23 Sep 2019
Accepted
19 Nov 2019
First published
19 Nov 2019

Chem. Commun., 2019,55, 14926-14929
Article type
Communication

Aldehyde-mediated bioconjugation via in situ generated ylides

S. Parmar, S. P. Pawar, R. Iyer and D. Kalia, Chem. Commun., 2019, 55, 14926
DOI: 10.1039/C9CC07443K

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