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Effector enhanced enantioselective hydroformylation

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Abstract

In this communication, we report rhodium DIMPhos complexes with an integrated DIM-receptor that can bind carboxylate containing effectors and their application in the rhodium catalyzed hydroformylation reaction. The binding of chiral effectors in non-chiral [Rh(DIMPhos)] catalysts does not lead to enantioselective hydroformylation, but the binding of either achiral or chiral effectors can significantly enhance the enantioselectivity induced by the chiral Rh-metal complexes. For example, the supramolecular complex [Rh]/[1SL3] displays high regio- and enantioselectivity in the hydroformylation of vinyl acetate (72% ee, and b/l >99), whereas in absence of this effector the ee is around 17%.

Graphical abstract: Effector enhanced enantioselective hydroformylation

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Publication details

The article was received on 18 Sep 2019, accepted on 29 Oct 2019 and first published on 29 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07327B
Chem. Commun., 2019, Advance Article

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    Effector enhanced enantioselective hydroformylation

    S. Bai, A. M. Kluwer and J. N. H. Reek, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07327B

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