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Assembly of branched ubiquitin oligomers by click chemistry

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Abstract

Ubiquitin monomers functionalized with an azide or multiple alkynes were utilized for the assembly of branched ubiquitin oligomers (K6/K11, K11/K48, K11/K63, K6/K11/K48) by click chemistry. The oligomers resist deubiquitylase-catalysed hydrolysis and exhibit stability in eukaryotic cell lysates.

Graphical abstract: Assembly of branched ubiquitin oligomers by click chemistry

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Publication details

The article was received on 17 Sep 2019, accepted on 09 Oct 2019 and first published on 09 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07303E
Chem. Commun., 2019, Advance Article

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    Assembly of branched ubiquitin oligomers by click chemistry

    X. Zhao, M. Scheffner and A. Marx, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07303E

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