Issue 87, 2019

Assembly of branched ubiquitin oligomers by click chemistry

Abstract

Ubiquitin monomers functionalized with an azide or multiple alkynes were utilized for the assembly of branched ubiquitin oligomers (K6/K11, K11/K48, K11/K63, K6/K11/K48) by click chemistry. The oligomers resist deubiquitylase-catalysed hydrolysis and exhibit stability in eukaryotic cell lysates.

Graphical abstract: Assembly of branched ubiquitin oligomers by click chemistry

Supplementary files

Article information

Article type
Communication
Submitted
17 Sep 2019
Accepted
09 Oct 2019
First published
09 Oct 2019

Chem. Commun., 2019,55, 13093-13095

Assembly of branched ubiquitin oligomers by click chemistry

X. Zhao, M. Scheffner and A. Marx, Chem. Commun., 2019, 55, 13093 DOI: 10.1039/C9CC07303E

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