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Issue 91, 2019
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Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

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Abstract

A palladium-catalyzed uniquely regioselective C–H alkynylation of indoles has been described. In this protocol, simple and readily available haloalkynes are employed as efficient alkynylating reagents, affording a series of functionalized 7-alkynylindoles in moderate to good yields. Moreover, further transformations of 7-alkynylated products were performed, which demonstrated the potential application of this method in organic synthesis.

Graphical abstract: Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

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Publication details

The article was received on 16 Sep 2019, accepted on 21 Oct 2019 and first published on 23 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07263B
Chem. Commun., 2019,55, 13769-13772

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    Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

    S. Fang, G. Jiang, M. Li, Z. Liu, H. Jiang and W. Wu, Chem. Commun., 2019, 55, 13769
    DOI: 10.1039/C9CC07263B

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