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Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

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Abstract

A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.

Graphical abstract: Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

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Publication details

The article was received on 13 Sep 2019, accepted on 04 Nov 2019 and first published on 04 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07199G
Chem. Commun., 2019, Advance Article

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    Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells

    K. Sambath, T. Zhao, Z. Wan and Y. Zhang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07199G

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