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Engineered Assembly of a Protein – Cucurbituril Biohybrid

Abstract

A crystalline biohybrid with a 4:1 protein:cucurbituril mass ratio is presented. This result was achieved by engineering additional cucurbit[7]uril (Q7) binding sites into a β-propeller protein. In contrast to the parent protein, Q7-controlled assembly of the engineered variant occurred in solution, as evidenced by NMR and SAXS measurements.

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Supplementary files

Publication details

The article was received on 13 Sep 2019, accepted on 04 Dec 2019 and first published on 04 Dec 2019


Article type: Communication
DOI: 10.1039/C9CC07198A
Chem. Commun., 2019, Accepted Manuscript

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    Engineered Assembly of a Protein – Cucurbituril Biohybrid

    F. Guagnini, S. Engilberge, K. Ramberg, J. Perez and P. B. Crowley, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC07198A

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