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Issue 98, 2019
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Integrating in situ formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy

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Abstract

Based on the Pt nanozyme modified mesoporous polydopamine in situ, a multi-functional nanoplatform was established, which could overcome tumour hypoxia by catalyzing overexpressed H2O2 in tumour cells to enhance photodynamic therapy. In vivo results confirmed that the tumour growth was inhibited efficiently by synergetic therapy.

Graphical abstract: Integrating in situ formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy

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The article was received on 12 Sep 2019, accepted on 11 Nov 2019 and first published on 12 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07125C
Chem. Commun., 2019,55, 14785-14788

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    Integrating in situ formation of nanozymes with mesoporous polydopamine for combined chemo, photothermal and hypoxia-overcoming photodynamic therapy

    X. Hu, Y. Lu, X. Shi, T. Yao, C. Dong and S. Shi, Chem. Commun., 2019, 55, 14785
    DOI: 10.1039/C9CC07125C

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