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Nucleophilic halo-Michael addition under Lewis-base activation

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Abstract

A simple and general conjugate nucleophilic halogenation is presented. The THTO/halosilane combination has shown the ability to act as a nucleophilic halide source in the conjugate addition to a variety of Michael acceptors. In addition, a straightforward diastereoselective halogen installation using α,β-unsaturated acyloxazolidinones as platforms has been developed.

Graphical abstract: Nucleophilic halo-Michael addition under Lewis-base activation

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Publication details

The article was received on 10 Sep 2019, accepted on 02 Oct 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07068K
Chem. Commun., 2019, Advance Article

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    Nucleophilic halo-Michael addition under Lewis-base activation

    V. Laina-Martín, I. Pérez, J. A. Fernández-Salas and J. Alemán, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07068K

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