Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action

Naama Karton-Lifshin; Shahaf Katalan; Ishay Columbus; Ravit Chen; Lea Yehezkel; Moran Madmon; Shai Dagan; Shlomi Elias; Gil Fridkin; Yossi Zafrani

doi:10.1039/C9CC07011G

Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action†

Naama Karton-Lifshin,*^a Shahaf Katalan,^b Ishay Columbus,^a Ravit Chen,^a Lea Yehezkel,^a Moran Madmon,^c Shai Dagan,^c Shlomi Elias,^a Gil Fridkin

*^a and Yossi Zafrani

*^a

Author affiliations

* Corresponding authors

^a Departments of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel
E-mail: naamal@iibr.gov.il, gilf@iibr.gov.il, yossiz@iibr.gov.il

^b Pharmacology, Israel Institute for Biological Research, Ness-Ziona 74000, Israel

^c Analytical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74000, Israel

Abstract

The ability of mono N-methyl-1,4-diazabicyclo[2.2.2]octane fluoride (Me-DABCOF, 1) to act as a bifunctional reagent that effectively and universally neutralizes both the persistent and extremely toxic blister agent HD and the nerve agent VX in nearly neutral aqueous solution, alumina powder or a hydrogel formulation, is described.

Chemical Communications

Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action†

Abstract

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Effective neutralization of chemical warfare agents (HD, VX) by Me-DABCOF: a small molecule with dual action

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