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Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

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Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

Graphical abstract: Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

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Publication details

The article was received on 09 Sep 2019, accepted on 03 Oct 2019 and first published on 04 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07009E
Chem. Commun., 2019, Advance Article

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    Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis

    W. Y. Kim, M. Won, A. Salimi, A. Sharma, J. H. Lim, S. Kwon, J. Jeon, J. Y. Lee and J. S. Kim, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07009E

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