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Sensing of citrulline modifications in histone peptides by deep cavitand hosts

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Abstract

Arrayed cavitand:fluorophore sensor complexes can selectively sense small citrulline modifications at arginine residues on post-translationally modified peptides. The sensor can differentiate between different numbers of citrulline modifications, and a simple two-fluorophore, 6-component array can effect cross-reactive discrimination between single modifications in aqueous solution.

Graphical abstract: Sensing of citrulline modifications in histone peptides by deep cavitand hosts

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Publication details

The article was received on 07 Sep 2019, accepted on 11 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC07002H
Chem. Commun., 2019, Advance Article

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    Sensing of citrulline modifications in histone peptides by deep cavitand hosts

    A. D. Gill, B. L. Hickey, S. Wang, M. Xue, W. Zhong and R. J. Hooley, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07002H

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