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Divergent synthesis of N-heterocyclic 1,6-enynes through a zinc-catalyzed decarboxylative A3 reaction

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Abstract

A zinc-catalyzed decarboxylative A3 reaction of cyclic amino acids, α,β-unsaturated aldehydes and terminal alkynes has been developed. A series of functionalized N-heterocyclic 1,6-enynes have been successfully obtained with excellent regioselectivities through this novel approach. In addition, the utility of this straightforward process is demonstrated by the preparation of a polycyclic nitrogen-containing heterocyclic compound.

Graphical abstract: Divergent synthesis of N-heterocyclic 1,6-enynes through a zinc-catalyzed decarboxylative A3 reaction

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Publication details

The article was received on 07 Sep 2019, accepted on 30 Oct 2019 and first published on 05 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC06985B
Chem. Commun., 2019, Advance Article

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    Divergent synthesis of N-heterocyclic 1,6-enynes through a zinc-catalyzed decarboxylative A3 reaction

    Z. Mao, Y. Liu, R. Ma, J. Ye, C. Si, B. Wei and G. Lin, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06985B

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