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Potent and selective PTP1B inhibition by a platinum(ii) complex: possible implications for a new antitumor strategy

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Abstract

Showing anti-proliferation activity against MCF7 cells better than cisplatin, a platinum(II) complex, [PtL(DMSO)Cl], was found to potently and selectively inhibit protein tyrosine phosphatase 1B (PTP1B), a putative target for anticancer agents, suggesting a new possible anticancer strategy based on platinum drugs.

Graphical abstract: Potent and selective PTP1B inhibition by a platinum(ii) complex: possible implications for a new antitumor strategy

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Publication details

The article was received on 06 Sep 2019, accepted on 23 Nov 2019 and first published on 25 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC06972K
Chem. Commun., 2020, Advance Article

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    Potent and selective PTP1B inhibition by a platinum(II) complex: possible implications for a new antitumor strategy

    C. Yuan, W. Wang, J. Wang, X. Li, Y. Wu, S. Li, L. Lu, M. Zhu, S. Xing and X. Fu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC06972K

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