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Issue 83, 2019
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Enhanced in situ detection and imaging of lipids in biological tissues by using 2,3-dicyanohydroquinone as a novel matrix for positive-ion MALDI-MS imaging

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Abstract

A fluorescent dye, 2,3-dicyanohydroquinone (DCH), was optimized for use as a new matrix for positive-ion MALDI-MS imaging, and it provided enhanced lipid detection and imaging in biological tissues. The properties of DCH, include a strong ultraviolet absorption, low volatility in a high-vacuum (∼10−7 mbar) source, super chemical stability, μm-sized matrix crystals, uniform matrix deposition, and high ionization efficiency for the detection of lipids.

Graphical abstract: Enhanced in situ detection and imaging of lipids in biological tissues by using 2,3-dicyanohydroquinone as a novel matrix for positive-ion MALDI-MS imaging

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Publication details

The article was received on 06 Sep 2019, accepted on 24 Sep 2019 and first published on 24 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06961E
Chem. Commun., 2019,55, 12559-12562

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    Enhanced in situ detection and imaging of lipids in biological tissues by using 2,3-dicyanohydroquinone as a novel matrix for positive-ion MALDI-MS imaging

    Y. Liu, L. Chen, L. Qin, M. Han, J. Li, F. Luo, K. Xue, J. Feng, Y. Zhou and X. Wang, Chem. Commun., 2019, 55, 12559
    DOI: 10.1039/C9CC06961E

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