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Issue 90, 2019
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Highly chemoselective, sterically sensitive NHC-catalysed amine acylation with pyridil

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Abstract

A new strategy for the protection of amines has been developed involving reaction with pyridil under the influence of N-heterocyclic carbene catalysis. The methodology is capable of distinguishing between two amines characterised by small differences in steric bulk and the resulting pyridoyl amides can be cleaved without requiring either strongly acidic or basic hydrolysis.

Graphical abstract: Highly chemoselective, sterically sensitive NHC-catalysed amine acylation with pyridil

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Article information


Submitted
05 Sep 2019
Accepted
15 Oct 2019
First published
25 Oct 2019

Chem. Commun., 2019,55, 13526-13529
Article type
Communication

Highly chemoselective, sterically sensitive NHC-catalysed amine acylation with pyridil

A. C. Maguire, V. Kumar and S. J. Connon, Chem. Commun., 2019, 55, 13526
DOI: 10.1039/C9CC06937B

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